Organic chemistry – Page 15
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ResearchSynthetic overhaul for hepatitis C drug could ease manufacturing demands
Chemists hope their five-step synthesis will increase global accessibility of uprifosbuvir and other lifesaving antivirals
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ResearchIodine revealed to be killer species that destroys tin-based perovskites
New insights into the mechanism that inactivates tin solar cells could lead to greener, more efficient devices
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ResearchAnti-electrostatic halogen bonding shown in solution for the first time
UV-vis spectroscopy and computational analysis explore nature of counterintuitive anionic interaction
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ResearchBlue light triggers ‘unprecedented’ reaction in old catalyst
Traditional iridium intermediate switches from allylic substitution to cross coupling when exposed to blue light
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OpinionFree radicals for post-translational modification
A technique for forming new carbon–carbon bonds at specific sites in proteins
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ResearchReaction confined between copper nanopyramids transforms carbon dioxide into ethylene glycol
Copper arrangement promotes C–C coupling and lowers formation barrier for a key intermediate
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FeatureComputer-guided retrosynthesis
Machine learning-based systems hope to outperform expert-guided reaction planning technology, finds Andy Extance
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ResearchUncovering new transformations by using electricity as a reagent
Song Lin explains the power of electrochemistry and how he fosters an inclusive environment for his research group
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ResearchRe-evaluating pyridine’s role in chlorination reaction
Well-established mechanism for chlorination using dichloroiodobenzene together with pyridine proven wrong
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OpinionExploring the potential of nanoarchitectonics
Combining self-assembly techniques from across scientific disciplines could allow us to precisely build any material structure
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ResearchPeptide ligation strategy unlocks diverse range of structural motifs
Approach expected to influence design of protein–protein interaction inhibitors
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ResearchNitrogen deletion reaction offers ‘new way to think about molecular editing’
Reagent inspired by decades-old research could save chemists a lot of headache when it comes to modifying molecules’ skeleton
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ResearchAutomated organic synthesis made easier with capsule-based console
Integrated console to synthesise drug-like molecules requires minimal user input
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ResearchAlkali cations boost carbon dioxide reduction into feedstock chemical
Discovery enables continuous-flow electrolysers with industrial potential
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ResearchAI enantioselectivity predictor set to power computational catalyst screening
Workflow involves mapping a reaction representation onto the activation energy of the stereocontrolling step
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ResearchRapidly alternating polarity stars in selective electrochemical reduction
Rapidly fluctuating AC targets specific carbonyl groups in the presence of several reducible groups
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NewsBots bring chemistry research tools to Twitter
Cheminformatic tool can deliver retrosynthetic analysis
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ResearchTri-agonist molecule designed to stimulate immune system crosstalk
Conjugation chemistry connects three different agonists around a triazine core
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ResearchAdding constraints to understand life’s chemical origins
Matt Powner wants to know if there are chemical rules that govern why certain synthetic strategies are embedded in biology