Organic chemistry – Page 5
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ResearchSkeletal editing that simply swaps aromatic carbons for nitrogens will aid drug discovery
Atom-swapping chemistry gains two new techniques that are ready to use
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ResearchPlasma–microdroplet fusion enables catalyst-free amine alkylations
Microdroplet chemistry improves selectivity of plasma-mediated alkylation reactions
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OpinionSlow march of the retrosynthesis robots
Software synthesis suggestions are hampered by biased and incomplete datasets
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ResearchElusive crystals provide structural evidence of global aromaticity in a macrocyclic hydrocarbon
Reduced forms of [24]paracyclophanetetraene provide fresh understanding of redox-based aromaticity switching
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ResearchActivating a chemical reaction by ‘flipping a switch’
A low-cost microfluidic reactor could cut the environmental footprint of synthesis by directing electrons via an external electric field
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ResearchUnexpected oscillations clarify mechanism of 100 year-old Fischer–Tropsch reaction
Discovery could pave the way to improved design of catalysts
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ResearchSimple substitution creates subset of rhodamine fluorophores with extreme solubility
Tetramethyl-substituted 3-phosphonorhodamines look set to find use in cellular imaging
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ResearchElectrophilic aromatic bromination study casts doubt on textbook intermediate
New computational evidence that electrophilic aromatic bromination actually occurs via an addition–elimination mechanism
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ResearchMOFs offer safer solution for handling fluorinated gases that can ‘tame the tiger’
Compounds vital in medicinal chemistry and imaging can be stored ready to use at room temperature
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ResearchEncapsulation drives visible light isomerisation in azobenzene photoswitch
Efficiency and selectivity of photoswitches boosted by confining light-sensitive structures into supramolecular capsules
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ResearchDoubly oxidised carbene tests the limits of the octet rule
Removal of two non-bonding electrons creates four-electron intermediate that could find use in synthesis
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Opinion(+)-iso-Phomopsene (and friends)
A non-obvious combination unleashes the power of electrocyclisation
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ResearchTransformation analysis reveals structural similarities in FDA-approved drugs
Reaction informatics tools combined to create a new method for mapping chemical space
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Research‘Transformative’ carbonyl cross-metathesis used to synthesise alkenes
Two new catalytic methods can produce a broad range of Z- and E-alkenes with remarkable cross-selectivity, paving the way for more efficient organic syntheses
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ResearchElectrochemical conversion of acids to alkenes achieved on kilogram scale
Efficient production of valuable alkenes achieved under mild conditions by reversing hydrocarboxylation reaction
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ResearchChemical oscillator’s tick-tock action catalyses reaction regular as clockwork
Small molecule oscillator can catalyse Knoevenagel condensation periodically without affecting the oscillation
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ResearchClever ligand design enables alcohol-directed C-H activation
Despite being the most common functional group in nature alcohols have proven difficult to functionalise
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WebinarAntimicrobial resistance: Exploring the One Health perspective and wastewater monitoring
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ResearchCopper catalyst behind general strategy for synthesising methylenecyclobutane compounds
Simple method that produces strained and synthetically-demanding molecules could be a boon for medicinal chemists
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ResearchMolecular cage seizes control in tetradehydro Diels–Alder reaction
Elegant method dodges harsh reaction conditions to assemble polycyclic scaffolds from simple linear precursors