Organic chemistry – Page 4
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ResearchRegioselective nitrogen-insertion reaction is latest addition to skeletal editing toolbox
Protocol transforms arenols into benzazepines
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ResearchRiding the microwave: three chemists share their stories
Disagreements surrounding non-thermal effects didn’t stop microwave reactors becoming a standard part of laboratory life
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ResearchSteroid separation made easy with photoswitchable coordination cage
Light-activated coordination cage purifies progesterone
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ResearchIon-beam experiments probe fundamentals of hydronium–hydroxide neutralisation
Researchers uncover new insights into one of chemistry’s most fundamental equilibrium reactions
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FeatureEditing polymer backbones
Changing the chemical makeup of a polymer backbone could revolutionise how we make, use and even recycle plastics. James Mitchell Crow reports
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ResearchPhotochemistry converts dry-cleaning solvent waste into useful chemicals
One-pot reaction offers way to upcycle industrial solvent waste
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OpinionAn unprecedented supramolecular structure brings new complexities to life
The transcription factor FOXP3’s interactions with DNA present more evidence of the importance of disorder
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ResearchExplainer: What are water microdroplets and why are chemists talking about them?
Researchers are struggling to agree on the underlying reasons for accelerated rates and altered reaction mechanisms in water microdroplets. Here’s what we do know and where open questions lie…
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ResearchWater microdroplet chemistry is contentious, here’s why
Are water microdroplets chemical dynamos or are their apparent effects experimental artefacts? Rebecca Trager investigates
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ResearchFirst GPT-4-powered AI lab assistant independently directs key organic reactions
Large language model takes control after being prompted to do Suzuki and Sonogashira couplings
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OpinionExploring new fragments of chemical space
How medicinal and process chemists are working together to build better drugs
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ResearchFast flow-chemistry set-up facilitates sulfur-fluoride click chemistry
A modular method makes the most of flow-chemistry to create click-ready reagents selectively and efficiently
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FeatureCubanes help drugs take the strain
Medicinal chemists are increasingly exploring strained ring systems, George Barsted reports, believing they can serve as replacements for conventional building blocks in pharmaceuticals
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CareersThe chemists creating knowledge-sharing websites
Speeding up scientific progress by sharing organic chemistry techniques, lab safety resources and computational procedures
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CareersOnline resources for chemists
A selection of tools, databases and advice sites to support your research
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ResearchNew silicon-based protecting group removable with blue light
Benzoyldiisopropylchlorosilane protects primary, secondary and tertiary alcohols, and also works alongside other protecting groups
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FeatureReaching into the non-covalent toolbox
Alongside supramolecular stalwarts, budding bonding forms are vying to be valuable, finds Andy Extance
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FeatureThe mechanical side of bonding
Synthetic chemists are finally mastering the assembly of interlocked molecules held together by the mechanical bond, find James Mitchell Crow
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NewsFuture House wants to build an AI biologist. They’re looking to a chemistry LLM for inspiration
ChemCrow has already recorded success researching, designing and producing an insecticide on its own